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Patient guide · Heart failure

Heart failure medications: what each one does

A plain-language tour of the medicines used for heart failure, what they do, what the studies showed, and the common worries people have about them.

Medically reviewed by Dr. Mohammed Alo, DO, FACCGuideline version 2022 AHA/ACC/HFSA + 2024 ACC ECDP

What heart failure medications is, in plain language

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What the current guidelines recommend

The main guideline is 2022 AHA/ACC/HFSA Heart Failure Guideline. **

The treatments, and why each one is recommended

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What guideline-based care looks like at a visit

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Red flags that a clinician is not following the guidelines

  • Selling supplements, peptides, or compounded drugs as treatment
  • Stopping proven medicines without a medical reason
  • Ordering unproven tests or “detox” programs
  • Telling you the guidelines are wrong without evidence

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Why choosing a guideline-based clinician matters

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Questions to ask your doctor

  1. Which guideline do you follow for heart failure medications, and what year is it from?
  2. Which of the recommended treatments am I on, and if not, why not?
  3. What targets are we aiming for, and how will we track them?
  4. What should make me call you before my next visit?
  5. Do you sell any supplements or compounded medicines? (A guideline-based clinic does not.)

Find a vetted heart failure specialist near you

Every heart failure specialist on DoctorDirectory.ai is license-verified, board-certified, and has signed a dated attestation to these guidelines. No patient reviews or star ratings, just facts you can check.

The guidelines behind this guide

Summaries in plain language, with links to the official documents and PDFs.

  • American College of Cardiology · 2024

    2024 ACC Expert Consensus Decision Pathway for Treatment of Heart Failure With Reduced Ejection Fraction

    • A practical guide to starting all four heart failure medicines quickly, often within weeks, rather than one at a time over months.
    • Explains how to handle low blood pressure, kidney numbers, and potassium so medicines are adjusted rather than stopped.
    • Sets out when to refer to an advanced heart failure team.
    Read the guidelinedoi:10.1016/j.jacc.2023.12.024
  • AHA / ACC / HFSA · 2022

    2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure

    • For heart failure with reduced pumping (HFrEF), four medicine classes are recommended together: an ARNI (or ACE inhibitor or ARB), a beta blocker, an MRA, and an SGLT2 inhibitor.
    • Each of the four lowers death and hospital stays on its own; together the benefit is large.
    • SGLT2 inhibitors are also recommended for heart failure with preserved pumping (HFpEF), which had few options before.
    • Devices (ICD, CRT), cardiac rehab, and treating iron deficiency are covered for the right patients.
    Read the guidelineDownload PDFdoi:10.1161/CIR.0000000000001063

All source guidelines

Find a vetted heart failure specialist near you

Every heart failure specialist listed has a verified license, board certifications on record, and a dated attestation to these guidelines. No reviews, no ratings.

This guide explains what the published guidelines recommend in plain language. It is educational, not medical advice, and it does not replace a visit with your own clinician. Guidelines change; check the review date above.

Something out of date? Tell us. Read our editorial policy.